Abstract
Histamine intoxication associated with seafood consumption represents a global health problem. The consumption of high concentrations of histamine can cause illnesses ranging from light symptoms, such as a prickling sensation, to death. In this study, gold–silver alloy-embedded silica (SiO2@Au@Ag) nanoparticles were created to detect histamine using surface-enhanced Raman scattering (SERS). The optimal histamine SERS signal was measured following incubation with 125 μg/mL of SiO2@Au@Ag for 2 h, with a material-to-histamine solution volume ratio of 1:5 and a phosphate-buffered saline-Tween 20 (PBS-T) solvent at pH 7. The SERS intensity of the histamine increased proportionally with the increase in histamine concentration in the range 0.1–0.8 mM, with a limit of detection of 3.698 ppm. Our findings demonstrate the applicability of SERS using nanomaterials for histamine detection. In addition, this study demonstrates that nanoalloys could have a broad application in the future.
Highlights
Histamine is a common biological substance involved in immune responses, physiological function, and neurotransmission
Reliable, rapid detection of histamine in fish is essential for food safety and public health, as well as for the global fish industry
The SiO2@Au@Ag NP material was prepared based on studies conducted by the Pham group revealing that SiO2@Au@Ag NPs exhibit a high Raman enhancement effect [39,43,44]
Summary
Histamine is a common biological substance involved in immune responses, physiological function, and neurotransmission. According to the European Union (EU) and the U.S Food and Drug Administration (FDA) standards, the concentration of histamine in fish for consumption must be
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