Abstract
Bioactive methyl cellulose and hydroxyethyl cellulose were successfully grafted onto PVC films using a two-step pathway. PVC surface was first modified with isothiocyanate in DMSO/water medium. Then, unmodified polysaccharides were directly grafted onto the thiocyanated surface in acetonitrile/DMSO mixture, in presence of DBTL as catalyst. The polysaccharide grafting onto the PVC surface was evidenced by contact angle measurements, AFM and XPS.
Highlights
Biofilm formation and infection is a problem of major concern covering several applications fields, especially the Biomaterials one
The chemical grafting of polysaccharides onto Polyvinyl chloride (PVC) surfaces was achieved in two steps (Scheme 1)
Isothiocyanate groups were introduced onto PVC surfaces
Summary
Biofilm formation and infection is a problem of major concern covering several applications fields, especially the Biomaterials one. In order to prevent this phenomenon, several strategies were developed in the past such as: antibiotic impregnation, surface coating by some metals like copper and silver or by some specific polymers like hydrogels These techniques exhibited some disadvantages such as antibiotic exhaustion, appearance of bacteria resistance phenomena, physical instability and lost of the biological activity in the long term. Polysaccharides represent a major natural, renewable and available resource in the polymer field Their applications vary from textile [1,2] to medical systems [3,4,5,6,7,8,9,10,11,12,13,14,15].
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