Facile Fabrication Route of Janus Gold-Mesoporous Silica Nanocarriers with Dual-Drug Delivery for Tumor Therapy.

Abstract

Codelivery of drugs using multifunctional nanoplatforms with anisotropic properties can produce synergistic effects and improve the antitumor activity of the drugs. In this work, Janus gold-mesoporous silica nanoparticles have been successfully synthesized via the Pickering emulsion method. The obtained Janus nanoparticles were further selectively assembled with thiol-β-cyclodextrin as a drug delivery vehicle for paclitaxel on gold domains, while the other mesoporous silica side with a mesoporous structure served as a drug delivery vehicle for doxorubicin. These synthesized Janus nanoparticles possess pH and near-infrared (NIR) dual-responsive release properties. Furthermore, the tumor-bearing mice treated with dual-drug-loaded Janus nanoparticles showed obvious tumor inhibition than single-drug-loaded ones. Histological analysis reveals no pathological changes in the vital organs of the mice. The outcome demonstrated that dual-drug-loaded Janus gold-mesoporous silica nanoparticles possessed a high therapeutic efficiency and excellent biocompatibility both in vitro and in vivo and could be used as an effective candidate for cancer therapeutics.