Facile fabrication of ZIF-8 MOF through varied molar ratio: A novel antibacterial agent against multidrug resistance bacteria

Abstract

Public health officials are now concerned about the rise in harmful bacterial strains that are resistant to antibiotic prophylaxis. As a result, there is an urgent need for the creation of efficient antibacterial agents. For which, numerous materials with nanoscale dimensions showing exceptional antibacterial capacity were planned and created to combat these multidrug resistant bacteria. Furthermore, bacteria cannot build immune responses within the nanomaterial bactericidal system because of special antimicrobial mechanism. Metal/metal oxide nanoparticulate systems, MOFs (metal organic frameworks) have received attention for their potent antibacterial properties and potential role as antibiotic replicants. In this study different molar ratio was taken to create for ZIF-8 MOF with rich mesoporous structure through solgel technique. PXRD, FTIR and SEM method were used to characterise the MOF. Due to the interaction of Zn2+ ions and imidazole, the as-synthesised ZIF-8C of (3:1); Zinc: HMIM molar ratio values exhibits better antibacterial efficacy than ZIF-8A (1:1) and B (1:3). It was discovered that the MIC and inhibition zone against S. aureus and E. coli were excellent. In addition to offering a viable option for biomedical implants, this discovery offers a promising pathway for suppressing drug resistance bacteria.