Abstract

AbstractA novel polymeric ionic liquid grafted porous polymer monolith has been facilely fabricated for mixed‐mode chromatography. The column is prepared from poly (glycidyl methacrylate‐co‐ethylene dimethacrylate) monolith through hydrolyzation of the epoxy moieties into hydroxyl groups, followed by "grafting from" polymerization of ionic liquid of 1‐vinyl‐3‐butylimidazolium chloride. Successful modification is characterized by scanning electron microscope, infrared spectroscopy, elemental analysis and mercury intrusion porosimetry. The HPLC performance of developed column is evaluated by separating acidic vitamin B analytes, neutral steroids and basic aromatic amines in mixed‐mode chromatography on a single column, respectively. The ionic liquid affords the monolith with both enhanced separation ability and improved column efficiency.

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