Abstract
Drug delivery systems (DDSs) have become hotpot in tumor chemotherapy to improve anti-tumor efficacy. It is still a challenge to control the diameter and distribution of the drug carriers. High performance reactions are expected to favor the precise design of the polymer structure, as well as the final crosslinked nanoparticles. Here, a facile approach was established to prepare the fluorescent traceable prodrug nanosponges for tumor intracellular pH/hypoxia dual-triggered drug delivery, via a high-performance reaction of isocyanate groups with fluorescent carbon quantum dots (CQD) as building block. The proposed doxorubicin (DOX) conjugated CQD-based nanosponges (DOX-Hy-CQD(ssPEGss)n) possessed excellent acid/GSH dual-triggered drug release, due to the dual-triggered disintegration inside tumor cells. As a result, the conjugated drug was released with an enhanced selective inhibition tumor cell proliferation than the free DOX. Furthermore, the fluorescence of the disintegrated CQD-contained small species might enable the real-time in-site imaging during drug release.
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