Facile approaches toward the synthesis of 6H-isoindolo[2,1-α]indol-6-ones via palladium-catalyzed carbonylation with carbon monoxide

Abstract

Two facile methods for the preparation of 6H-isoindolo[2,1-α]indol-6-ones were developed. In the first protocol, 6H-isoindolo[2,1-α]indol-6-ones were prepared from 2-(2-iodophenyl)-1H-indoles via palladium-catalyzed intramolecular aminocarbonylation. The second involves intermolecular carbonylation of indoles with iodobenzenes followed by intramolecular cross-dehydrogenative-coupling.