Facile and Proficient Synthesis of Some New 1,2,4-Triazole- 3-Thiones Derivatives Using [H2-TMDP] [HPO4] Ionic Liquid

Abstract

Delving out novel methodologies for the synthesis of potent heterocyclic compounds is cornerstone concept of contemporary organic chemistry. In this pursuit, we have delved out proficient and expeditious synthesis of some new 1,2,4-triazole-3-thiones derivatives using efficient and recyclable catalyst [H2-TMDP] [HPO4] as acidic ionic liquid. Proficiency of catalyst was proved by producing new 1,2,4-triazole-3-thiones derivatives in excellent yield by reacting thiosemicarbazide with various aldehydes or ketones in water: ethanol (1:1) at room temperature rapidly. The novel catalyst demonstrated rapid and efficient synthesis of a new series of 1,2,4-triazole-3-thione derivatives, achieving excellent yields of 88–96% within a short reaction time of 8–13 min. Shorter reaction time, simple work-up procedure, high yields, environmentally benign solvent system, high TOF, recyclability of catalyst, superb atom economy, and efficiency are the remarkable aspects of the protocol.