Abstract
The lack of targeting selection to lysosome limits the application of graphene quantum dots (GQDs) in the diagnosis and treatment of lysosome-related disease. In this study, we developed a facile, environmentally friendly and large-scale method to prepare [Formula: see text]-aminomorpholine (Am)-modified GQDs (Am-GQDs) via a simple hydrothermal method. The physicochemical, optical, biocompatible and targeted imaging properties were evaluated systematically. The results indicated that the synthesized Am-GQDs had a uniform size distribution and the size was around 2[Formula: see text]nm. In addition, the synthesized Am-GQDs had excellent optical properties, fluorescent stability, and good biocompatibility. More importantly, they can selectively target and image lysosome in a relatively short coculture time with cells, demonstrating their application potential in the diagnosis and treatment of lysosomal-related diseases.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
