Abstract
Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and azocanes. This review highlights some facile and green synthetic routes for the synthesis of unsubstituted, multisubstituted and highly functionalized saturated cyclic amines including one-pot, microwave assisted, metal-free, solvent-free and in aqueous media.
Highlights
Saturated cyclic amines are prominent bioactive motifs in many medicinal compounds and natural products (Figures 1 and 2)
This review aims to highlight the green synthetic methodologies including one-pot, multi-component, solvent-free, microwave-assisted and synthesis in aqueous media for single-nitrogen containing saturated cyclic amines
Vast arrays of applications in various scientific disciplines have triggered the development of new methods for their facile synthesis
Summary
Saturated cyclic amines are prominent bioactive motifs in many medicinal compounds and natural products (Figures 1 and 2). They are attractive building blocks employed to construct other molecules of medicinal or biological interest [1]. A large number of pharmacologically active natural and synthetic cyclic amines are in regular clinical use (Figure 3) [9]. They have been utilized as antibiotics, anticancer, analgesics, antidepressants, anti-HIV, anti-HCV agents, etc. A variety of cyclic amine-containing compounds find applications as insecticides, pesticides, rodenticides and herbicides [12,13,14,15,16]
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