Abstract
We report the synthesis of benzimidazole derivatives using zinc triflate as an efficient catalyst. One-pot synthesis of 2-substituted benzimidazole derivatives from o-phynelyenediamine and substituted aldehydes were developed under zinc triflate in ethanol solvent at reflux temperature.
Highlights
Benzimidazole derivatives have received much interest in the field of medicinal chemistry [1,2]
Substituted benzimidazole derivatives are evaluated by their ability to inhibit gastric H+/K+ ATPase and by blocking the gastric acid secretion [4]
As part of our research program in developing various synthetic methodologies, we report the synthesis of benzimidazoles using zinc triflate as an efficient catalyst (Scheme 1)
Summary
Benzimidazole derivatives have received much interest in the field of medicinal chemistry [1,2]. Benzimidazole derivatives carrying different substituent’s in the benzimidazole structure were associated with a wide range of biological activities including anticancer, antiviral, antibacterial, antifungal, antihelmentic, anti-inflammatory, antihistaminic, proton pump inhibitor, antioxidant, antihypertensive and anticoagulant activities. Solvent-free synthesis of benzimidazoles under microwave irradiation using Yb(OTf)3 [17], KSF clay [18], metal halide supported alumina [19] and solid support [20,21] has been reported Many of these methods suffer from one or more drawbacks such as requirement of strong acidic conditions, long reaction times, low yields, tedious workup procedures, requirement of excess amounts of reagents, and use of toxic reagents, catalysts or solvents. The catalyst is known as an efficient catalyst in the literature for various organic transformations [22,23,24,25,26]
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