Facile and efficient aerobic one-pot synthesis of benzimidazoles using Ce(NO3)3·6H2O as promoter

Guilherme M Martins,Thiago Puccinelli,Rogério A Gariani,Fernando R Xavier,Claudio C Silveira,Samuel R Mendes

doi:10.1016/j.tetlet.2017.04.020

Facile and efficient aerobic one-pot synthesis of benzimidazoles using Ce(NO3)3·6H2O as promoter

Guilherme M Martins, Thiago Puccinelli + Show 4 more

https://doi.org/10.1016/j.tetlet.2017.04.020

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Journal: Tetrahedron Letters	Publication Date: Apr 6, 2017
Citations: 37

Affiliation: Universidade Federal de Santa Maria, Universidade do Estado de Santa Catarina

#Series Of Benzimidazoles #Efficient Oxidant + Show 8 more

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Abstract

A series of 2-substituted benzimidazoles was synthesized under aerobic conditions, by simply heating 1,2-diaminobenzene and aldehydes in DMF at 80°C, employing Ce(NO3)3·6H2O as promoter and atmospheric air as an efficient oxidant. The procedure afforded the products from good to excellent yields. Furthermore, this new economic and eco-friendly protocol avoids the use of toxic metal catalysts, as well as additional bases and oxidants.

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