Abstract
Copper catalyzed the [3 + 3] coupling of the oxime esters with β-CF3-acrylonitrile toward divergent fluoroalkyl-substituted 2-aminopyridines was described. This redox-neutral coupling conditions with the acrylonitrile affording the trifluoromethylated 2-aminopyridines, respectively, under the reductive conditions, difluoromethylated 2-aminopyridines were obtained. The reactions occurred under mild conditions with high functional-group compatibility and excellent regioselectivity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
