Abstract
Wilson disease usually presents with neurologic or hepatic manifestations. Magnetic resonance imaging (MRI) of the brain is very informative in diagnosiing of this disease, especially in patients with neurological features. High T2 signal intensity in the corpus striatum is the most commonly encountered MRI finding. The 'face of the giant panda' sign is seen on axial T2-weighted MRI, and results from abnormal signal intensities in the midbrain. Though uncommon, the sign is considered as the pathognomonic MRI sign of Wilson disease.
Highlights
An 18-year-old man was admitted with a gradually progressive tremor and abnormal movements of the limbs of 6 months’ duration
The sign was originally described by Hitoshi et al.; it is produced as a result of high signal intensity in the tegmentum with preserved normal signal intensity in the red nuclei and lateral portion of the pars reticulata of the substantia nigra, and hypointensity of the superior colliculi.[3]
In Wilson disease (WD), iron deposition is more significant than copper for producing T2 hypointensity
Summary
An 18-year-old man was admitted with a gradually progressive tremor and abnormal movements of the limbs of 6 months’ duration. There was no evidence of sensory or pyramidal tract involvement. He had no past or family history of liver disease.
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