Abstract
A label-free fiber-optic Fabry–Perot interferometric (FPI) immunosensor is proposed by layer-by-layer (LBL) self-assembly of a suspended chitosan and polystyrene sulfonate membrane at the tip of a hollow fiber. Immunoglobulin G (IgG) was immobilized on the polyelectrolyte substrate and the detection of target anti-immunoglobulin G (anti-IgG) was monitored through the measurement of substrate's effective optical thickness. The sensitivity and specificity of the sensor were studied using correlated and non-correlated anti-IgG/IgG pair. Sensitivity of 0.033μm/(pg/mm2) and limit of detection of 0.005nM was achieved with the sensor displaying minimal response toward non-correlated anti-IgG. The results demonstrate the feasibility of the sensor for immunosensing.
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