Abstract
A sustainable hybrid material based on carbonized cotton cloth/zeolite imidazolate framework-71/Fe3O4/polythionine (CC/ZIF-71/Fe3O4/PTh) was synthesized and applied in ultrasound-assisted dispersive magnetic solid-phase extraction (USA-DMSPE) followed with high performance liquid chromatography-ultraviolet detection (HPLC-UV) for simultaneous quantitation of diclofenac (DIC) and febuxostat (FEB) in human plasma. The surface of CC was modified with nanoarrays of zeolite imidazolate framework-71/Fe3O4/Polythionine. At first, an in situ synthesis of ZIF-71 in the presence of CC was carried out, and followed with magnetization process and oxidative polymerization of thionine. The nano-modifier agents improved the merits of the sorbent involving stability, porosity, mast transfer, π–π interactions and selectivity of CC. Characterizations of the hybrid sorbent were examined with different instrumental techniques. The limits of detection (LODs, S/N = 3) were recognized 2.1 ng mL−1 for DIC and 3.7 ng mL−1 for FEB. Acceptable linearity (0.992 ≤ r2 ≤0.996) and relatively broad dynamic ranges of 10.0–1800.0 ng mL−1 and 15.0–2500.0 ng mL−1 were achieved for DIC and FEB, respectively. Reasonable intra-assay (≤7.2%, n = 9) and inter-assay (≤7.5%, n = 9) precisions as well as appropriate accuracies (≤8.0%) were provided illustrating applicability of the current approach for analytical purposes. Eventually, CC/ZIF-71/Fe3O4/PTh was employed as four-part sorbent for the assessment of DIC and FEB in human plasma at trace levels and subsequently main pharmacokinetic data such as T1/2, Tmax,Cmax, and AUC0–24 of these drugs were comprehensively investigated.
Highlights
Increase in concentration level of uric acid in serum causes gout which is a common arthritic disease
Literature survey exhibits that different analytical protocols involving gas chromatography, high performance liquid chromatography followed with mass spectrometry (HPLC-MS/MS), RP-HPLC with ultraviolet and uorescence detections, highperformance thin-layer chromatography (HPTLC) and spectrophotometric methods have been reported for the determination of FEB and DIC in real samples.[7,8,9,10,11,12,13,14,15,16,17]
As a consequence of the existence of nanoarrays, which utilized as modi er agents, the surface of cotton cloth (CC)/Zeolitic imidazolate frameworks (ZIFs)-71, CC/ZIF-71/Fe3O4 and CC/ZIF-71/Fe3O4/ PTh seem jagged in comparison with the CC
Summary
Literature survey exhibits that different analytical protocols involving gas chromatography, high performance liquid chromatography followed with mass spectrometry (HPLC-MS/MS), RP-HPLC with ultraviolet and uorescence detections, highperformance thin-layer chromatography (HPTLC) and spectrophotometric methods have been reported for the determination of FEB and DIC in real samples.[7,8,9,10,11,12,13,14,15,16,17]. Paper them in special analytical purposes.[24,25,26,27] the introduced extractors suffer from some disadvantages such as lack of reusability, low surface area-to-volume ratio, insufficient porosity, high cost of synthesis, unacceptable selectivity, etc In this regard, carbonized cotton cloth (CC) as a novel class of carbon-based material, seems superior substance for fabricating an efficient and reusable hybrid material for extraction and enrichment of target compounds form complex matrices.[28] CC can be obtained from cotton, linen, cloth or felt which are available, and it bene ts from some features including low cost of fabrication, simple synthesis route, considerable extraction ability along with properties which correspond to the concept of green chemistry.[29,30]. The possibility of the currently designed sorbent was perused by measuring main pharmacokinetic data of FEB and DIC in human plasma
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