Abstract
Lanthanide-doped upconversion nanoparticles (UCNPs) synthesized with hydrophobic organic ligands lacks solubility in aqueous media. To address this problem, we attempted to fabricate chitosan/NaYF4:Yb/Tm UCNPs hybrid microspheres (CS/NaYF4:Yb/Tm HMs) by use of a Pickering emulsion system to expand their applications in the biomedical field. The characterization of samples revealed that as-synthesized UCNPs coated with F127, a nonionic surfactant, exhibited good colloidal properties, high crystallinity and characteristic emission upconversion fluorescence, displaying an overall blue color output. The NaYF4:Yb/Tm UCNPs were successfully entrapped on the surface of chitosan microspheres by the gelling of Pickering emulsion droplets, preserving good upconversion luminescent properties. The CS/NaYF4:Yb/Tm HMs combine the biological compatibility of chitosan and photoluminescence of UCNPs, possessing great potential in biomedical applications.
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