Abstract
A thermoresponsive glycopolymer poly-(N-isopropylacrylamide-co-6-O-vinylsebacoyl D-glucose) (poly-NIPAM-co-VSEG; PNE) has been prepared by free radical polymerization process, and subsequently processed into nanofibers with poly-L-lactide-co-ε-caprolactone (PLCL) using electrospinning. The thermoresponsive glycopolymer materials have been characterized by Fourier transform infrared (FTIR) spectroscopy, 1H NMR, and scanning electron microscopy (SEM). And the lower critical solution temperature (LCST) of these thermoresponsive materials was also measured. The nanofibers containing PNE can greatly selective recognize with lectin Concanavalin A (Con A), and the adsorbed Con A can be easily eluted by 1 M glucose solution. These results indicate that PNE can separate and purify proteins, and also the temperature sensitive characteristic has the potential to achieve the intelligent control.
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