Abstract
Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Au NPs) through polyethylene glycol (PEG) linking for targeted molecular computed tomography (CT) imaging was developed. The prepared TZ-PEG-Fe3O4@Au NPs were fully characterized and cytocompatibility, X-ray attenuation measurement, and in vitro cell targeting ability were analyzed. The findings showed that the synthesized NPs, with a size of less than 100 nm, were non-toxic at specific concentration ranges, and exhibit better X-ray attenuation intensity than iodine-based contrast agents at the same concentration. The created targeted NPs can be employed as a contrast agent for molecular targeted CT imaging of cancer cells expressing the human epidermal growth factor receptor 2 (HER-2).
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