Fabrication of Stress and Temperature Measurement Sensors and Possible Integration with Fabricated Biodegradable Drug Delivery Device

Abstract

ABSTRACT This paper presents the design and fabrication of flexible skin conductance and temperature sensor using PDMS with a minimized skin contact area and increased device flexibility. The design and fabrication of reservoir-based (RB) drug delivery system (DDS) using microfabrication technology is also presented in this paper with possible future integration with these sensors. While the sensors can be used for the measurement of galvanic skin response for detecting emotional activity and monitoring of human stress in daily life, the RB-DDS can be used for delivering drug like insulin in a controlled and sustained manner to the target site. The sensor performance has been experimentally verified using the BITalino (r)evolution Board Kit while the DDS has been tested in-vivo and in-vitro. A comparative study on the sticking property of PDMS with aluminium was also conducted by exposing PDMS with oxygen and argon plasma.