Abstract
Fabrication of environmental sensitive and controllable drug release systems is urgently needed. In this paper, thermosensitive and magnetic response drug release systems were fabricated via layer-by-layer technique using acetylsalicylic acid (AA) intercalated ZnAl-LDH as core, poly (N-isopropylacrylamide) (PNIPAM) and AA micelles as well as small size ZnAl-LDH sheets as building blocks of the shell. By forming anionic micelles, cationic PNIPAM macromolecules were sandwiched in the LDH sheets with cationic charges which provided a novel way of fabrication of drug release systems. The characteristics of the building blocks, the fabrication process and the release behaviors of the as-prepared drug release systems were characterized in detail. Due to the micro-environmental difference of AA in the core and shell of the systems, step-by-step release behaviors were observed. Also the drug release systems showed obvious temperature and magnetic field dependent responsibility. The obtained assembly is a potential drug release system.
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