Abstract
Fabrication of solid lipid nanoparticles by hot high shear homogenization and optimization by Box–Behnken design: An accelerated stability assessment
Highlights
The superficial fungal infections are major challenges in the field of dermatology, pediatric care, and primary care (Cohn, 1992; Drake et al, 1996)
The design matrix of Box–Behnken design (BBD) consisted of 27 runs by employing 5 responses, i.e., average particle size, polydispersity index, zeta potential, percent encapsulation efficiency, and percent drug loading
BBD was employed to optimize the formulations of Miconazole nitrate (MCN)-loaded solid lipid nanoparticles (SLN) which consisted of three levels, four factors (Table 1), and three center points
Summary
The superficial fungal infections are major challenges in the field of dermatology, pediatric care, and primary care (Cohn, 1992; Drake et al, 1996). According to the survey of National Centre for Health Statistics, fungal infections were considered the most prevalent topical disease in patients of age between 1 and 74 years (Pfaller and Sutton, 2006). Solid lipid nanoparticles (SLN) are established as one of the particulate carrier systems that have many merits over other NDDS (Zhang et al, 2006). SLN are surfactant-stabilized colloidal systems made of lipids that remain solids at both body and room temperatures (Wissing et al, 2004). They range in size from 50 to 1,000 nm.
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