Fabrication of Silver Nanoparticles with Cotton for Antibacterial Wound Dressing

Abstract

Nosocomial infections are presently an important health issue which is caused by the transfer of infection by patient, fomites and surgical materials in hospital. In solving these problems, silver nanoparticles play an inevitable role in the development of antibacterial and dressings materials by nanofabrication to minimize the risk factor in nosocomial infections. Nanofabrication can be defined as a bottom-up process to fabricate the material of interest from ionic level to nanoscale level with superior property. In the present study, silver nanoparticles have been fabricated into cotton fabrics for antibacterial wound dressing materials. Fabrication of silver nanoparticles into cotton fabrics was analyzed using SEM, EDAX, FTIR and UV-Vis spectroscopy. It was found that 20-nm -sized fine particles incorporated in cotton fiber without damaging the texture of the fiber. Antibacterial property of fabrics was tested against clinically isolated pathogens, Escherichia coli and Staphyloccocus aureus by disc diffusion and colony forming count method. The results proved that antibacterial activity was found against tested pathogens. This technology may apply for the development of silvernanoparticle- incorporated surgical materials and wound dressing materials to overcome nosocomial infections, secondary infection and drug storing articles. Keywords: Nanofabrication, Silver nanoparticles, Cotton fabrics, Antibacterial, Wound dressing.