Abstract
AbstractWe report a dual‐responsive, self‐assembled nano micelle for co‐delivery of doxorubicin (DOX) and a previously reported cyclopalladated anti‐cancer agent (CP). In this micelle system, doxorubicin and CP were electrostatically complexed to form a hydrophobic core while a conjugation of polyethylene glycol and β‐cyclodextrin (CD) was designed to construct the hydrophilic out‐layer and stabilize the micelle. The interaction between pegylated CD and DOX‐CP composite was achieved via inclusion of ferrocene moiety by CD, which could be broken by stimulating ROS that is over‐expressed in many cancer cell lines. Moreover, the DOX‐CP adduct can be destabilized under an acidic environment that exists in most solid tumors, which can further disassemble the micelle and release the two drugs. The fabricated micelle was characterized by TEM, DLS and its stimulus‐responsive characteristic were confirmed by drug‐release profile. The in vitro cellular cytotoxicity was also evaluated, which showed improved anti‐cancer effect of drug‐loaded micelle compared to free drugs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.