Abstract
Fabrication of Poly (Diallyldimethylammonium Chloride) (PDDA) Functionalized Multi-Walled Carbon Nanotubes Paper Electrode for Simultaneous Detection of Dopamine and Ascorbic Acid
Highlights
Dopamine (DA) is one of the most important neurotransmitters and plays a vital role in the mammalian central nervous, cardiovascular, renal and hormonal systems [1,2,3]
A paper-based electrode based on nanocomposite, comprising of carboxylated multi-walled carbon nanotubes (MWNTs) and poly (PDDA), has been successfully developed for simultaneous detection of dopamine (DA) and ascorbic acid (AA) in 0.1 M phosphate buffer solution (PBS)
The fabrication of PDDA/MWNTs electrodes involves two steps: PDDA absorbed onto the surface of carboxylated MWNTs and drop-casting the aqueous mixture of PDDA/MWNTs onto the paper
Summary
Dopamine (DA) is one of the most important neurotransmitters and plays a vital role in the mammalian central nervous, cardiovascular, renal and hormonal systems [1,2,3]. Parkinson’s disease, schizophrenia and depression occur at very low level of DA concentration [4,5,6]. The development of a sensitive and selective method for determination of DA molecules is highly desirable for diagnostic research. The detection of DA using differential pulse voltammetry (DPV) methods has been widely reported due to their low cost [9], rapid analysis and high sensitivity. The co-existence of ascorbic acid (AA) in blood samples with a concentration of 100 – 1000 times higher than that of DA as well as similar oxidation potentials make their simultaneous detection with high
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