Abstract
TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, pamidronic acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X‐ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA‐immobilized TiO2/HA composite nanofiber mat (TiO2/HA‐P). The potential of TiO2/HA‐P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA‐P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA‐P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HA‐P nanofiber mat has the potential for use as a therapeutic bone implant.
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