Abstract
The fabrication conditions of bone-haemostasis sheet were examined by using (i) phosphoryl oligosaccharides of calcium (POs-Ca), sugar-containing hydroxyapatite (s-Ca10(PO4)6(OH)2: s-HAp) derived from POs-Ca and (ii) natural plant-derived polymers (locust bean gum (LBG), guar gum (GG) and alginate (AG)). The sol, which had been prepared by dissolving 2 mass% LBG/GG and 2 mass% AG into 200 cm3 deionized water and then by agitating at the speed of 20 000 r.p.m., was immersed into 3 mass% POs-Ca solution at room temperature for 24 h; it was hydrothermally treated at 100°C for 5 h, and then freeze-dried at −50°C for 24 h to form porous composite sheet. The microscopic observation showed that the pore sizes were controlled in the range of 5–100 µm by the optimization of LBG/GG ratio. The composite sheet showed the noted uptake of simulated body fluid (1426%) at 37.0°C and also the human blood. Thus, the porous composite sheet was found to be a promising candidate of the bone haemostasis, on the basis of the data of haemostasis, uptake ability of SBF and solubility in acetic acid–sodium acetate buffer solution.
Highlights
When the bones are cut during the surgery operation, large amounts of bleeding occur from the bone’s vessel
Prior to checking the fabrication conditions of porous composites by using locust bean gum (LBG), guar gum (GG) and AG, the effect of the agitation (20 000 r.p.m.) on the appearances of LBG, GG and AG sol was examined with the results being shown in figure 1, together with the molecular structures
The viscosities of LBG and GG solutions were examined by Elfak et al [11], who reported that the intrinsic viscosity of GG was higher than that of LBG
Summary
When the bones are cut during the surgery operation, large amounts of bleeding occur from the bone’s vessel. E.g. beeswax, and the problem exists with regard to the risks of infections and bone healing. Apart from such 2 animal-derived materials, the synthetic alkylene oxide copolymers, which readily achieve haemostasis and do not inhibit bone healing, have started to be commercially available [1]. This material is hydrophilic and water soluble, but is ended up eliminating from the body in the short period of time. The present authors, paid attention to the novel plant-derived haemostasis materials having bio-absorbability, bone healing (bone regeneration) ability and no risks of infections
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
