Abstract
An electrochemical nanobiosensor is described for the voltammetric determination of miRNA-128 as the cancer biomarker. Aptamer chains were immobilized on the surface of a glassy carbon electrode (GCE) via gold nanoparticles/magnetite/reduced graphene oxide (AuNPs/Fe3O4/RGO). FTIR and XRD analysis were used for the characterization of synthesized nanomaterials. Square wave voltammetry (SWV) was used to characterize the modified GCE in a label-free method. The results indicate that the modified working electrode has high selectivity and for miRNA-128 over other biomolecules. The hexacyanoferrate redox system, typically operated at around 0.3 V (vs. Ag/AgCl) was used as an electrochemical probe. The limit of detection (LOD) and linear detection range are 0.05346 fM and 0.1 to 0.9 fM, respectively.
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