Abstract
As a versatile nanofiber manufacturing technique, electrospinning has been widely used for tissue engineering scaffold fabrication. However, it remains challenging to create scaffolds with anisotropic microstructure close to native tissues. This article presented a novel electrospinning configuration to generate fibrous mat with microstructure gradient. A series of proof-of-concept tests were performed to investigate the effects of process parameters on the gradient of nanofiber morphology and mat attributes. The technique developed in this study showed great potentials as a fabrication platform for heterogenous nanofiber products.
Highlights
With the growing demand for organ repair and replacement, a reliable alternative to the golden standard allograft has been yearned for many years.[1]
Scaffolds could mimic the extracellular matrix (ECM) of native tissue and exert certain mechanical and biological influences to modify the behavior of the cell phase.[2,3,4]
It showed that a minimum of TAD was required to form the nanofibers
Summary
With the growing demand for organ repair and replacement, a reliable alternative to the golden standard allograft has been yearned for many years.[1]. Most native ECMs found in tissues (e.g. sciatic nerve, bone, tendon, and cartilage) have anisotropic composition and architecture. This heterogeneous structure is considered to optimize the material’s response to external loading,[7] to enable specific cell migration during tissue regeneration,[8,9] to regulate cell growth and communication,[10] and to influence the mechanical properties.[11] It remains challenging to fabricate scaffolds with controlled gradient in nanofiber structure mimicking the natural tissues. Several methods of generating gradient scaffolds have been reported.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
