Abstract
Using Particle Replication In Nonwetting Templates (PRINT®) technology, multiphasic and regio-specifically functionalized shape-controlled particles have been fabricated that include end-labeled particles via post-functionalization; biphasic Janus particles that integrate two compositionally different chemistries into a single particle; and more complex multiphasic shape-specific particles. Controlling the anisotropic distribution of matter within a particle creates an extra parameter in the colloidal particle design, providing opportunities to generate advanced particles with versatile and tunable compositions, properties, and thus functionalities. Owing to their robust characteristics, these multiphasic and regio-specifically functionalized PRINT particles should be promising platforms for applications in life science and materials science.
Highlights
The following reagents were used as received: 2,2-diethoxyacetophenone (DEAP, Aldrich), 2-aminoethyl methacrylate hydrochloride (AEM, Aldrich), fluorescein o-acrylate (Aldrich), dimethyl sulfoxide (DMSO, Aldrich), 1-hydroxycyclohexyl phenyl ketone (HCPK, Aldrich), poly(ethylene glycol) monomethyl ether monomethacrylate (Mn1000 g mol−1, PEG1000, Polysciences), pH 8.60 borax buffer (Ricca Chemical), polystyrene (Mn10 500 g mol−1, Polymer Standards Service), chlorobenzene (Aldrich) and N-hydroxysuccinimide (NHS)-rhodamine (Pierce)
A small aliquot of a monomer solution was deposited on the surface of the mold and spread uniformly by laminating onto a poly(ethylene terephthalate) (PET) sheet
The PET sheet was peeled back effectively removing the excess monomer from the land areas and leaving the mold cavities filled with monomer solution
Summary
The following reagents were used as received: 2,2-diethoxyacetophenone (DEAP, Aldrich), 2-aminoethyl methacrylate hydrochloride (AEM, Aldrich), fluorescein o-acrylate (Aldrich), dimethyl sulfoxide (DMSO, Aldrich), 1-hydroxycyclohexyl phenyl ketone (HCPK, Aldrich), poly(ethylene glycol) monomethyl ether monomethacrylate (Mn1000 g mol−1, PEG1000, Polysciences), pH 8.60 borax buffer (Ricca Chemical), polystyrene (Mn10 500 g mol−1, Polymer Standards Service), chlorobenzene (Aldrich) and N-hydroxysuccinimide (NHS)-rhodamine (Pierce). The PFPE prepolymer resin (FluorocurTM, Liquidia Technologies, Inc.) was mixed with 0.1wt% DEAP photoinitiator before use. Liquidia Technologies Inc. provided a 200 mm polymer replica master with hexagonal close-packed hexnut features (2.5 μm flat-to-flat, 1 μm height) spaced by 1.5 μm. Scanning electron microscopy (SEM) imaging was accomplished on a Hitachi model S-4700. Palladium/gold (Pd/Au) alloy was deposited using a sputter coater (Model 108 Auto Sputter Coater, Cressington Scientific Instruments). Fluorescence and optical images were obtained using a Zeiss Axioskop 2 MAT incident light microscope fitted with an AxioCam MR digital camera
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