Fabrication of multi-compartmental vesicles via RAFT method in polymerization-induced self-assembly

Abstract

Synthetic polymer nanomaterials have sparked considerable attention because to their use in a wide range of fields, including medication delivery, sensors, nano reactors, and catalytic supports. A popular approach for creating polymer nanoparticles is self-assembly of block copolymers in a diluted solution. Generally, the preparation of fine structural nanoparticles involves several steps, including the synthesis of block copolymers, exhausting purification to obtain perfect block copolymers, diluting the obtained block copolymers in a suitable solvent, and then cautiously replacing the decent solutes with a selective solvent. Furthermore, typical polymer nano-object manufacturing is frequently done in high dilution (concentration is usually below 1%). The procedure for producing block copolymers and allowing them to self-assemble is combined into one stage by polymerization-induced self-assembly, which significantly streamlines the creation of polymeric nanostructures and enables the fabrication of such materials at high concentrations (solid concentrations of 10–50%). This work used styrene as the monomer, E/W at a weight ratio of 7:3 as the solvent, and polyethylene glycol (PEG45-PETTC) as the macro-RAFT reagent to successfully create multi-chambered vesicles.