Abstract
Polymer substrates with patterned surface have been utilized to control the cell positioning and spreading for cell adhesion. This paper presents a novel method to fabricate micrometer-scale wavy patterned surfaces with continuous and smooth shape by using a standing surface acoustic wave (SAW) device with the assistance of ultraviolet (UV) polymerization. L929 mouse fibroblasts are then cultured onto these patterned surfaces for durations of 24h and 48h, respectively. For the comparison, cells cultured on the flat surfaces without patterns are also carried out. Results showed that cells aligned well with the direction of micro-wavy patterns compared to those on the flat surfaces, thus demonstrated that the fabricated micro-wavy patterns could be utilized for enhanced cell culturing. Further, the enhanced cell adhesive, alignment, and spreading on the patterned surface could be applied for the investigation of cell-cell interaction and communication in tissue engineering.
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