Abstract
A facial, versatile, and universal method that breaks the substrate limits is desirable for antifouling treatment. Thin films of functional poly-p-xylylenes (PPX) that are deposited using chemical vapor deposition (CVD) provide a powerful platform for surface immobilization of molecules. In this study, we prepared an alkyne-functionalized PPX coating on which poly (sulfobetaine methacrylate-co-Az) could be conjugated via click chemistry. We found that the conjugated polymers were very stable and inhibited cell adhesion and protein adsorption effectively. The same conjugation strategy could also be applied to conjugate azide-containing poly (ethylene glycol) and poly (NIPAAm). The results indicate that our method provides a simple and robust tool for fabricating antifouling surfaces on a wide range of substrates using CVD technology of functionalized poly (p-xylylenes) for biosensor, diagnostics, immunoassay, and other biomaterial applications.
Highlights
When biomaterials are in contact with the biological environment, nonspecific protein adsorption and cell adhesion occur unavoidably, often leading to malfunction of biomedical devices
We demonstrated that other polymers such as poly and poly (N-isopropylacrylamide) could be conjugated on a surface via the same approach to provide specific surface functions
Alkyne-PPX was conjugated with pSBAz by click chemistry for 8 h
Summary
When biomaterials are in contact with the biological environment, nonspecific protein adsorption and cell adhesion occur unavoidably, often leading to malfunction of biomedical devices. Antifouling surfaces that resist nonspecific protein adsorption and cell adhesion are demanded to reduce adverse biological responses [1]. An important feature of antifouling surfaces is their ability to bind water molecules tightly. Poly (zwitterions) with high water binding capacity via electrostatic interactions have been shown to be excellent antifouling materials [5,6,8,9,11,12]. Many research efforts have focused on immobilization of antifouling polymers on biomaterial surfaces to reduce unwanted biological interactions
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