Fabrication of iron tin oxide/tin oxide intertwined graphitic carbon nitride hybrid composite electrocatalyst for electrochemical detection of 5-aminosalicylic acid in human urine and pharmaceutical tablet samples

Abstract

Background5-Aminosalicylic acid (5-ASA) is known as a cornerstone in the treatment of inflammatory bowel diseases, to prevent the synthesis of cytokines and inflammatory mediators. However, an overdose of this drug is a rare and unique condition in patients and can lead to kidney failure. Therefore, a rapidly sensitive method is needed for the monitoring of 5-ASA. Methodswe synthesized novel iron tin oxide/tin oxide (FeSnO3/SnO2, FSO/SO) nanostructures via a facile precipitation method. Further, the FSO/SO intertwined two-dimensional (2D) graphitic carbon nitride (g-C3N4) hybrid composite electrocatalyst was developed by the wet-chemical process. The proposed materials were characterized by XRD, Raman, XPS, FESEM, TEM and TGA. Further, the glassy carbon electrode (GCE) modified with FSO/SO/g-C3N4 was revealed to sensitive detection of 5-ASA in PBS (pH-7) by CV, LSV and DPV methods. Significant findingsThe surface modification of FSO/SO/g-C3N4/GCE can enhance the synergistic action of different dimensional active catalysts. The limit of detection (LOD=3σ/S) proposed sensor was found to be 0.00625 µM and 0.0075 µM via LSV and DPV methods, also the calculated sensitivity has 3.428 µA µM−1 cm−2 and 2.857 µA µM−1 cm−2 respectively. The developed sensor demonstrated outstanding feasibility test results for detecting 5-ASA in samples of human urine and mesalamine tablet using the DPV method.