Abstract
This work aims to fabricate a novel antibiotic-free antibacterial strategy for the construction of multifunctional coating on micro-nanosheets generated titanium (M-Ti) substrates (M-Ti@ZI) using indocyanine green (ICG)-loaded zeolitic imidazole frameworks-90 (ZIF-90@ICG) under near-infrared (NIR) light irradiation. Based on the results, M-Ti@ZI presented promising pH-responsive release properties of Zn2+, as well as strong antibacterial abilities against methicillin-resistant Staphylococcus aureus (MRSA). Importantly, the antibacterial effects on MRSA were significantly improved after NIR irradiation due to the photothermal effect of ICG. Moreover, M-Ti@ZI substrates presented good cytocompatibility and induced osteogenesis both in vitro and in vivo. Therefore, the ZIF-90@ZI has promising and broad clinical applications in the orthopedic field for improving the antibacterial and osteogenic abilities of Ti-based implants.
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