Abstract
The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.
Highlights
Skin is the largest organ of the human body and it is an essential barrier featured with immunologic, sensorial, and protective capability [1]
The results from this study revealed that human adipose stromal cells grown on the nanofibers have higher proliferation and migration rate, elongated morphology, and higher formation of extracellular matrix (ECM) components, all of which happen during the process of wound healing [140]
Nanofibers prepared from biopolymers suffer from poor mechanical properties, insignificant antibacterial effects, making them inappropriate for wound dressing and skin regeneration
Summary
Skin is the largest organ of the human body and it is an essential barrier featured with immunologic, sensorial, and protective capability [1]. There is an urgent need to develop wound dressings suitable for the accelerated wound healing mechanism of chronic wounds. Examples of bioactive dressings ings include nanofibers, membranes, wafers, foams, hydrogels, sponges, and films [10]. The main limitation of biopolymer-based nanofibers is their poor mechanical perforAn ideal wound dressing must demonstrate good mechanical properties Thewound poor mechanical properties of imitate biopolymer-based wound dressings can. The poor mechanical properties of biopolymer-based nanofiber wound dressings can be significantly improved by crosslinking themthem withwith synthetic polymers. Several studies have demonstrated that the biopolymer-based hybrid nanofibrous wound dressings possess interesting properties (e.g., imitating extracellular matrix, good antimicrobial effects, good wound healing properties, etc.) for improved wound care
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