Abstract
Abstract Folic acid (FA) functionalized magnetic chitosan (CS) microcapsules (FA-MCMCs) were fabricated by a simple sonochemical method. FA molecules were coupled onto the outer walls of microcapsules as targeting ligands. Oleic acid (OA) modified Fe 3 O 4 nanoparticles (OA–Fe 3 O 4 NPs) and hydrophobic drugs were encapsulated into microcapsules. The obtained FA-MCMCs had a well-defined spherical morphology with the average size of 0.8 μm. Moreover, FA-MCMCs showed an excellent supermagnetic and molecular targeted property. Cellular uptake of C6-loaded FA-MCMCs proved that FA-MCMCs could be endocytosed into the cells with the folate receptors selectively. Besides, FA-MCMCs showed a good pH-responsive and thermosensitive property. The developed FA-MCMCs could be a promising candidate for anti-cancer drugs carriers.
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