Fabrication of floating tablets using bark extract of azadirachta indica for the treatment of peptic ulcer

Abstract

Targeted release of drugs in the upper intestines can be achieved by using floating drug delivery systems (FDDS). A. indica has been the most commonly used traditional medicine for the treatment of peptic ulcers in rural India. This study's A. indica bark extract floating tablets are designed to keep drug in the stomach longer, boost its bioavailability, and target the ulcer in the stomach. Hydrocolloids (such as HPMC and carbopol 934P were employed to expand an FDDS, as were sodium bicarbonate (NaCl) and citric acid. They were examined for their pre-compression properties, physical qualities, buoyancy, lag time, in vitro release, and swelling index before compression. It was determined which formulations worked best for the various HPMC viscosity grades, carbopol 934P concentrations and mixtures. Experiment results showed that F2 was able to maintain drug release (95 percent) for 12 hours and remained buoyant at the same time. The improved formulation (F2) did not alter buoyancy time, drug content, and in vitro dissolution after three months at 40°C/75 percent RH. Tablets are cost-effective and may solve absorption issues. A. indica bark extract significant reduced ulcer index and percentage of ulcer formation in animals.