Fabrication of drug eluting medical device for treating stenosis by 3D printing and dip coating using aspirin as a model drug

Abstract

3D printing is a new innovative manufacturing method for fabrication of customized medical devices. The customized medical devices & long-lasting implantable devices.has increasing demand for addressing some critical cases in surgeries.
 The main aim of this work was to explore the potential of 3D printing in Fabrication of medical devices and prosthetics. The characters of the polymers, the features of softwares were studied.
 The study showed that drug loading into filament through hot melt extrusion and followed by 3D printing has many defects such as denaturing of drugs at higher printing temperatures.
 The invention discloses the dip coating process after fabrication of a 3D printed polymer structure. The drug release depends up on the surface area of the device, coated polymer, concentration of drug and thickness of the coat.
 The method for preparing the personalized drug eluting coronary stent / Bone wedges / Braces comprises the step that according to image data of coronary angiogram or volume rendered data from CT scans. The designing was done by adopting a QCA technique for measuring the diameter of a diseased coronary artery and reconstructing in a three-dimensional manner. According to indexes such as lesion vascular diameter, lesion length and lesion vascular pattern, a personalized coronary stent can be made for each patient in a customized manner and a stent most suitable for the lesion state of a patient can be prepared.
 Keywords: 3D printing, manufacturing method, Fabrication of medical devices