Abstract
The core-shell structure molecularly imprinted magnetic nanospheres towards hypericin (Fe3O4@MIPs) were prepared by mercapto-alkyne click polymerization. The shape and size of nanospheres were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). The nanospheres were analyzed by FTIR spectroscopy to verify the thiol-yne click reaction in the presence or absence of hypericin. The Brunauer–Emmet–Teller (BET) method was used for measuring the average pore size, pore volume and surface area. The Fe3O4@MIPs synthesized displayed a good adsorption capacity (Q = 6.80 µmol·g−1). In addition, so-prepared Fe3O4@MIPs showed fast mass transfer rates and good reusability. The method established for fabrication of Fe3O4@MIPs showed excellent reproducibility and has broad potential for the fabrication of other core-shell molecularly imprinted polymers (MIPs).
Highlights
Imprinted polymers (MIPs), mimicking a principle similar to antibody–antigen recognition, are synthesized via polymerization to create specific binding sites with memory of the template molecules during the synthetic process of polymers [1]
Fe3 O4 @Molecularly imprinted polymers (MIPs) were synthesized according to the procedure described in Scheme 1
The results showed that the click polymerization method used to fabricate Fe3 O4 @MIPs was reproducible and that nanospheres polymerization used to
Summary
Imprinted polymers (MIPs), mimicking a principle similar to antibody–antigen recognition, are synthesized via polymerization to create specific binding sites with memory of the template molecules during the synthetic process of polymers [1]. Hypericin (Hyp) has gained increasing interest from researchers due to its bioactivities, such as the core-shell magnetic[18], molecularly imprinted nanosphere, which possesses adsorption antidepressant antiviral, antisepsis, antiphlogosis and antitumor propertiesgreat [19,20,21]. For. Since example, the firstbyreport in [24], click reaction has been broadly applied in many fields such using Fe3O4 as the core and polydopamine as the shell, we established a simple way to as polymersynthesize chemistry, functional materials, surface modification and biochemical sensors the core-shell magnetic molecularly imprinted nanosphere, which possesses great because capacity (denoted as Fe3 O4 @MIPs) can be fabricated by click polymerization between (1) 3,5-diethynyl-pyridine, Based on our previous works [23,31], we envision that core-shell magnetic MIP nanospheres and (2) tris(denoted (3-mercaptopropionate), on the surface of MNPs in the presence of Hyp. Fe3 O4 @MIPs as Fe3O4@MIPs) can be fabricated by click polymerization between (1).
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