Abstract
AbstractIn this study, two types of carbon dioxide‐based amphiphilic block copolymers (CO2‐based copolymers), monomethoxy poly(ethylene glycol)‐block‐poly(propylene carbonate) (mPEG‐b‐PPC) and allyloxy poly(ethylene glycol)‐block‐poly(propylene carbonate) (aPEG‐b‐PPC), were synthesized by one step copolymerization. The structure of the copolymer was determined by FTIR spectrum and 1H NMR characterization. On this base, the development of the preparation and controlling capability of CO2‐based copolymers controlled‐release particles were studied. Drug‐loaded particles were formed by two types of CO2‐based copolymers, which possess sustained‐release function. Given that the surface layer of aPEG‐b‐PPC particles has double bonds, shell cross‐linked particles were prepared by cross‐linking reaction of the allyloxy. Compared with aPEG‐b‐PPC particles, aPEG‐b‐PPC shell cross‐linked particles showed that the release rate was more slowly and suppressed the phenomenon of an initial burst release.
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