Abstract
In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core-shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r 1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.
Highlights
During the last decade, various functional nanoparticles (NPs) with interesting magnetic, optical, and chemical properties have been extensively applied to biomedical areas including imaging, diagnosis, and therapy [1,2,3,4,5]
NPs covered with biocompatible polyethylene glycol (PEG) have been used in cell labeling studies [6,7]
In a typical fabrication procedure, the spherical Gd2O3 spheres with an average diameter of 243±38 nm (Fig. 1(a)) are used as the template cores
Summary
Various functional nanoparticles (NPs) with interesting magnetic, optical, and chemical properties have been extensively applied to biomedical areas including imaging, diagnosis, and therapy [1,2,3,4,5]. “positive” contrast agents (CAs) are widely used to improve the contrast between tissues using T1-weighted magnetic resonance imaging (MRI). The higher density of magnetic ions is the main advantage of using paramagnetic gadolinium oxide NPs as a “positive” CA [6]. Design of new CAs for biomedical application requires a controlled synthesis, with a suitable surface modification in order for them to remain nontoxic and biocompatible. We design and construct multifunctional carbon coated Gd2O3 particles. We believe that a unique particle system composed of Gd2O3 core and coated with thin carbon layer would have great potential in both bio- and nanoscience
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