Fabrication of biological detection chip based polymer nanostructures via nanoimprint lithography

Abstract

High resolution and high precision polymer nanostructures has unique chemical and physical properties, playing an important role in nano-optics, nano-photonics, and high sensitivity biological detection. This paper demonstrated a novel fabrication method of biological detection chip based on polymer nanostructures via nanoimprint lithography. High precision nanostructures such as nanopillar arrays were prepared on chip film via nanoimprint lithography. The polymer nanostructures were used to enhance adhesion to cancer cells, which is low-cost and suitable for mass production. The replication polymer was biocompatibility materials that has no effect on cells. The experiment results show that the nanopillar arrays chip can adhere lung cancer cells in the size of 10-15 μm to achieve the purpose of filtering and detecting cells. Results of the experiments show that this new biological detection chip has potential applications of cancer detection, targeted therapy, food safety testing, and environmental monitoring.