Fabrication of bioactive porous bredigite (Ca7MgSi4O16) scaffold via space holder method

Abstract

AbstractBredigite has been recently evaluated as a biodegradable ceramic with high mechanical strength, biocompatibility, bioactivity and excellent cell behavior. The objective of this research was to fabricate a nanostructured bredigite scaffold for bone repair and restoration via the space holder technique. The crystallite size, phase composition, particle size, pore morphology and pore size distribution of the scaffold were characterized using X-ray diffraction, as well as transmission and scanning electron microscopy. The results showed the fabrication of a highly interconnected porous scaffold, with a total porosity of about 86%, a pore size of about 400–600 μm, and the compressive strength of about 1.1 MPa. The prepared scaffold with nanosized structure and high porosity level leading to a high specific surface area could be used as an ideal scaffold for bone regeneration in bone tissue engineering applications.