Abstract
Dietary fibers are known for their therapeutic role in colon ailments and enhancement of gut microbial growth. Dietary fiber psyllium has been explored as dietary supplement for the treatment of gastrointestinal problems like constipation, colon inflammation and diverticulitis. Hence, in the present work, psyllium has been used to design the hydrogel based drug delivery (DD) system. The antibiotic drug cefuroxime encapsulated arabinoxylan psyllium-phosphated network hydrogels were prepared for drug delivery to colon problems to synergize the effect of antibiotic drug. These grafted and crosslinked copolymers were characterized by solid state 13C NMR, FTIR, TGA-DTG, DSC, SEM, AFM and XRD. The presence of FTIR peak at 1153.30 cm-1 (due to –PO of poly (BMEP) and at 977.53 cm-1 (due to P–O–C of poly (BMEP) and absence of peak at around 130 ppm in solid state 13C NMR confirmed the incorporation of the phosphate polymers [poly (bis [2-methacryloyloxy] ethyl phosphate [(poly (BMEP)] in to copolymer hydrogels. XRD results indicated the amorphous nature of the polymers. The mesh size (ξ) and crosslink density (ρ) of network hydrogel was found 74.763 nm and 0.74 × 10-5 mol/cm3 respectively which indicated the porous nature of the hydrogels. Polymers showed 0.50 N mucoadhesion with mucosal membrane. The haemolysis was found less than 5% during blood-polymer interaction indicated blood compatible nature of polymers. The sustained diffusion of cefuroxime was observed with non-Fickian mechanism with Korsmeyer-Peppas best fit kinetic model. Overall, results indicated the suitability of arabinoxylan psyllium-phosphated polymers for drug delivery applications.
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