Fabrication of antibacterial Janus bandages with high wound healing performances by facile single-side electrospray PDMS coating

Abstract

Bandages are widely utilized to cover local wounds. However, most bandages have limited capacities to promote wound healing, which may occasionally cause serious wound infections. Accordingly, herein, we demonstrated a facile electrospray method to fabricate an antibacterial Janus bandage that could simultaneously remove wound bed exudate and prevent wound infection. The advanced bandage was only composed of an adhesive strip and an antibacterial Janus cotton fabric, whose single side was controllably electrospray-coated with a thin polydimethylsiloxane coating. The Janus cotton fabric exhibited a high one-way transport index (R = 1068%), suggesting its appropriate directional liquid moisture transport ability, and excellent air permeability. Furthermore, in vitro experiments demonstrated that the advanced bandage had adequate biocompatibility and exhibited sustained release of hydroxypropyltrimethyl ammonium chloride chitosan, which considerably enhanced the proliferation of fibroblasts. As a proof-of-concept, this bandage was employed to drain the exudate from Staphylococcus aureus (S. aureus)-infected mice wounds and kill S. aureus in these wounds, which significantly accelerated wound healing. The simple fabrication process of unique bandage reveals it has considerable potential as a next-generation bandage for healing local wounds clinically.