Abstract
Metallic nanoparticles are considered as active supports in the development of specific chemical or biological biosensors. Well-organized nanoparticles can be prepared either through expensive (e.g., electron beam lithography) or inexpensive (e.g., thermal synthesis) approaches where different shapes of nanoparticles are easily obtained over large solid surfaces. Herein, the authors propose a low-cost thermal synthesis of active plasmonic nanostructures on thin gold layers modified glass supports after 1 h holding on a hot plate (~350 °C). The resulted annealed nanoparticles proved a good reproducibility of localized surface plasmon resonance (LSPR) and surface enhanced Raman spectroscopy (SERS) optical responses and where used for the detection of low concentrations of two model (bio)chemical molecules, namely the human cytochrome b5 (Cyt-b5) and trans-1,2-bis(4-pyridyl)ethylene (BPE).
Highlights
Biosensors studie in the field of light-matter interactions require the development of active and sensitive metallic nanostructured substrates due to their ability to exhibit, in response to a light wave excitation, a localized surface plasmon resonance (LSPR) characterized by a collective oscillation of electrons in the metal and by a strong enhancement of local electromagnetic fields in the vicinity of nanoparticles [1,2,3,4]
The aim of the present work is the development of active plasmonic substrate tailored with stable and randomly disposed annealed gold nanoparticles for biological and environmental aim of theThe present work is the development of active plasmonic substrate tailored with main advantages of proposed substrates consist on the protocol simplicity, stable and randomly annealed gold nanoparticles forsizes biological reproducibility anddisposed formation of nanoparticles of controllable particle over large and scaledenvironmental surfaces applications
LSPR/SERS spectroscopies and annealed gold films for 1 h at 350 ◦ C using pre-treated glow- discharge cleaned glasses. These substrates were carefully characterized in function of different parameters: initial metal thickness deposition, resulted sizes and distance between neighboring nanoparticles
Summary
Biosensors studie in the field of light-matter interactions require the development of active and sensitive metallic nanostructured substrates due to their ability to exhibit, in response to a light wave excitation, a localized surface plasmon resonance (LSPR) characterized by a collective oscillation of electrons in the metal and by a strong enhancement of local electromagnetic fields in the vicinity of nanoparticles [1,2,3,4]. Beside the physical investigations [5], the metallic nanoparticles (NPs) have been used in the development of either sensitive chemical [6,7,8] and biological LSPR [9,10,11,12,13,14] or surface enhanced Raman spectroscopy (SERS) [15,16,17,18,19] nanosensors It has been reported on the coupling between nanoparticles when strong SERS-exaltations of electromagnetic fields were noticed [20,21,22,23,24]. It is well-known that the localized surface plasmons are radiative and can be coupled directly with the light due to the surface roughness
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