Fabrication of aligned structure tissue engineering scaffold by electrospinning using magnetic field

Abstract

Event Abstract Back to Event Fabrication of aligned structure tissue engineering scaffold by electrospinning using magnetic field Zhen Li1*, Lei Zhang1* and Feng Lin1* 1 Tsinghua University, Department of Mechanical Engineering, China Introduction: The technology of electrospinning is an important method in fabrication of the tissue engineering scaffold, having the superiority of small diameter, high porosity and so on. Especially, the structure of aligned fiber has many advantages, such as it is good for the adhesion and proliferation of cells. But the random non-woven fabric structure is got using the ordinary method of electrospinning, and that how to fabricate aligned fiber is one of the hot issues in this field. The purpose of this study is to fabricate the aligned fiber using the mothed of electrospinning in the static magnetic field and analyze the influence of the magnetic field. Materials and Methods: In this study, we fabricated fibers by electrospinning using the PLGA and 1,4-dioxide solution. In order to verify the effect of the static magnetic field in the process of electrospinning, different kinds of materials of magnets (ferrite and NdFeB, we also used plastic block as contrast) and different magnetic field distribution were used in this experiment. And in order to analyze the theoretic effect of the magnetic field, the scale of the force and the movement effect on the fiber were analyzed and estimated by establishing a model of fiber’s deposition. Result and Discussion: In the experiment, some good experimental parameter was found in the electrospinning of the PLGA and 1,4-dioxide solution. But it is shown that we got the same aligned fibers whether the same magnetic poles is opposite or different magnetic poles is opposite. It illustrated that the main factors of the aligned structure are physic structure of the receiver and the electric field distribution instead of the magnetic field. The model calculating result showed that the direction of the force couldn’t make the fiber despite along the magnetic field between the two magnets. And the force is too small to control the movement of the fiber. Conclusions: According to the experimental and theoretical results, the influence of the fiber structure by magnetic field is small and this conclusion is opposite to many study in this field. In this study, some extra experiment made the conclusions before not valid any more and the theory of the magnetic electrospinning needs further researches.​ Keywords: Tissue Engineering, Structure, nanofiber, Scaffold Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Synthetic scaffolds as extracellular matrices Citation: Li Z, Zhang L and Lin F (2016). Fabrication of aligned structure tissue engineering scaffold by electrospinning using magnetic field. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01791 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Zhen Li, Tsinghua University, Department of Mechanical Engineering, Beijing, China, zhen-li15@mails.tsinghua.edu.cn Dr. Lei Zhang, Tsinghua University, Department of Mechanical Engineering, Beijing, China, stoneszhang@mail.tsinghua.edu.cn Dr. Feng Lin, Tsinghua University, Department of Mechanical Engineering, Beijing, China, Email1 Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zhen Li Lei Zhang Feng Lin Google Zhen Li Lei Zhang Feng Lin Google Scholar Zhen Li Lei Zhang Feng Lin PubMed Zhen Li Lei Zhang Feng Lin Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.