Abstract
Asymmetric nanocarriers with different functions can achieve synergistic effect in cancer treatment. In this study, asymmetric carbon-silica (C-SiO2) carriers were prepared for drug delivery and combining therapy. The C-SiO2 carriers presented acorn-like structure with dendritic mesoporous silica hat and carbon body. The carbon body render the carriers photothermal effect. The prepared C-SiO2 carriers with size around 130 nm have improving cell uptake efficiency, and excellent biocompatibility. After loading doxorubicin hydrochloride (DOX), menthol (LM) was used to seal the loaded drug (DOX@C-SiO2-LM). LM coating can melt above the phase transition temperature, leading to the release of loaded cargo. The DOX@C-SiO2-LM displayed temperature/NIR-triggered drug release.
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