Abstract
A microfluidic device with integrated spectrophotometric elements has been injection molded in poly(methyl methacrylate) (PMMA). The strategy for producing the device combined the direct photopatterning, replica molding techniques and a rapid cooled release mechanism in conjunction with material−material transfer to form a multilayer epoxy master on an injection mold insert. An injection-molded flow cell consisting of 1800 diffractive elements patterned on 25-μm-high PMMA pillars was produced. The design incorporated a large cross sectional surround, simplifying the alignment and bonding procedure. The absorbance range of one of the devices was standardized against a commercially available visible spectrophotometer at 605 nm to increasing concentrations of Nile blue perchlorate A dye in aqueous solution. The detection limit for a new integrated device was 1.2 × 10-6 m/Lof the mentioned dye.
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